附註:Includes bibliographical references (pages 91-93).
Executive summary -- Women's health initiative -- IOM study -- Findings and suggestions -- Clinical trial -- Observational study -- Community prevention study -- Recommendations -- Responses to the statement of task -- Description of the NIH women's health initiative -- History of Institute of Medicine involvement -- Committee selection and participation -- Statement of task -- Committee activities -- Clinical trial -- Rationale -- General issues -- Integration of the CT with other components of the WHI -- Design and methods -- Factorial design -- Sample characteristics -- Proposed analytic techniques -- Ethics: consent and stopping rules -- Minority analysis plan -- Specifying the relationship of intervention an effect -- Outcome definition and measurement -- Recruitment and retention -- Adherence -- Secular trends -- Provision of health care services to participants -- Study management -- Dietary modification branch -- Rationale -- Design and methods -- Weighing benefits and uncertainties of the breast cancer arm -- Hormone replacement therapy branch -- Rationale -- Design and methods.
(cont) Threats to completion of HRT branch -- Use of HRT in elderly women -- Calcium and vitamin D supplement branch -- Rationale -- Design and methods -- Threats to successful completion of CaD branch -- Clinical trial cost -- Data available to committee deliberations -- WHI cost relative to other larger studies -- Clinical center funding -- Total cost -- Potential causes of budget shortfalls -- Observational study -- Rationale -- Design and method -- Cost -- Recommendations -- Community prevention study -- Rationale -- Design and methods -- Cost -- Recommendations -- Concluding remarks -- Response to the statement of task -- Societal context -- Efficacy and effectiveness -- Public health choice versus individual choice -- Considerations beyond science -- Clinical trial exclusion criteria -- U.S. House of Representatives Appropriations Committee -- Statement of task -- Documents received by the Institute of Medicine from the National Institutes of Health -- Meeting participants June, July and August 1993 -- Primary and subsidiary hypotheses of the women's health initiative clinical trial.
(cont) Women's health initiative committees -- NIH-sponsored women's health studies -- NIH cost and FTE summary for Vanguard clinical centers -- NIH power calculations -- Women's health initiative clinical coordinating center and Vanguard clinical centers principal investigators -- Abbreviations and acronyms -- Committee and staff biographies.
