附註:"This project was supported by Cooperative Agreement No. CR827277-01 between the National Academy of Sciences and the U.S. Environmental Protection Agency"--Title page verso.
Includes bibliographical references.
""Copper in Drinking Water""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""THE CHARGE TO THE COMMITTEE""; ""THE COMMITTEE'S APPROACH TO ITS CHARGE""; ""THE COMMITTEE'S EVALUATION""; ""Health Effects of Excess Copper""; ""Recommendations""; ""Physiological Role of Copper""; ""Recommendations""; ""Sensitive Populations""; ""Recommendations""; ""Risk Characterization""; ""Recommendations""; ""1 Introduction""; ""CHEMICAL AND PHYSICAL PROPERTIES""; ""SOURCES OF COPPER IN DRINKING WATER""; ""COMMITTEE'S APPROACH TO ITS CHARGE""; ""STRUCTURE OF THE REPORT""; ""REFERENCES""
""2 Physiological Role of Copper""""ESSENTIALITY""; ""BIOCHEMISTRY AND PHYSIOLOGY""; ""FACTORS AFFECTING BIOAVAILABILITY""; ""Effect of Age""; ""Dietary and Other Interactions""; ""CONCLUSIONS""; ""RECOMMENDATIONS""; ""REFERENCES""; ""3 Health Effects of Copper Deficiencies""; ""TERATOGENESIS OF COPPER DEFICIENCY""; ""Causes of Copper Deficiency""; ""Copper in Prenatal Development""; ""Drug-Induced Copper Deficiency""; ""Disease-Induced Copper Deficiency""; ""Copper-Diet Interactions""; ""Gene-Induced Copper Deficiency""; ""Human Copper Deficiency and Teratogenesis""
""Primary Dietary Copper Deficiency""""HEALTH EFFECTS OF COPPER DEFICIENCIES IN ADULTS""; ""CONCLUSIONS""; ""REFERENCES""; ""4 Disorders of Copper Homeostasis""; ""MENKES DISEASE""; ""OCCIPITAL HORN SYNDROME""; ""WILSON DISEASE""; ""GENETIC CHARACTERISTICS OF WILSON AND MENKES DISEASES""; ""HETEROZYGOTES FOR WILSON DISEASE""; ""ACERULOPLASMINEMIA""; ""TYROLEAN INFANTILE CIRRHOSIS""; ""INDIAN CHILDHOOD CIRRHOSIS""; ""IDIOPATHIC COPPER TOXICOSIS""; ""OTHER GENETIC DISORDERS""; ""DISEASE-INDUCED CHANGES IN COPPER HOMEOSTASIS""; ""CONCLUSIONS""; ""RECOMMENDATIONS""; ""REFERENCES""
""5 Health Effects of Excess Copper""""ACUTE TOXICITY""; ""Case Reports and Population-Based Studies""; ""CHRONIC TOXICITY""; ""Reproductive and Developmental Toxicity""; ""Genotoxicity, Mutagenicity, and Carcinogenicity of Copper""; ""Sensitive Populations""; ""Carriers of Genetic Defects in Copper Homeostasis""; ""Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD)""; ""ANIMAL STUDIES""; ""Toxicity in Animals""; ""Reproductive and Developmental Toxicity""; ""Neurotoxicity""; ""Carcinogenicity""; ""Mechanisms and Animal Models for Copper Toxicity""; ""Mechanism of Acute Copper Toxicity""
""Mechanism of Chronic Copper Toxicity""""CONCLUSIONS""; ""RECOMMENDATIONS""; ""REFERENCES""; ""6 Risk Characterization""; ""COPPER DEFICIENCY""; ""COPPER TOXICITY FROM SINGLE OR SHORT-TERM EXPOSURE""; ""COPPER TOXICITY FROM CHRONIC EXPOSURE""; ""Sensitive Populations""; ""Carriers of the Wilson-Disease Gene and Other Genetically Sensitive Groups""; ""Infants""; ""Chronic Liver Disease""; ""Glucose-6-Phosphate Dehydrogenase Deficiency""; ""Implications for the MCLG""; ""CHRONIC COPPER EXPOSURE THROUGH TAP WATER""; ""DIETARY CONTRIBUTION AND TOTAL COPPER INTAKE""; ""Formula-Fed Infants""
