Animal cell technology :products from cells, cells as products. Proceedings of the 16th ESACT Meeting : April 25-29, 1999, Lugano, Switzerland

• 作者: European Society of Animal Cell Technology.
• 其他作者: Bernard, A.
• 出版: New York : Kluwer Academic ©2002.
• 稽核項: 1 online resource (lxxii, 564 pages) :illustrations.
• 標題: Proteins Biotechnology. , Pharmaceutical biotechnology. , Proteins Biotechnology -- Congresses. , SCIENCE , Electronic books. , Proteins , Conference papers and proceedings. , Animal cell biotechnology , SCIENCE Biotechnology. , Pharmaceutical biotechnology Congresses. , Animal cell biotechnology. , Animal cell biotechnology Congresses. , Biotechnology , Pharmaceutical biotechnology , Biotechnology.
• ISBN: 0306468751 , 9780306468759
• ISBN: 0792360753 , 9780792360759
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• 附註: Includes bibliographical references and index. Recombinant pharmaceutical protein overexpression in an IRF-I proliferation controlled production system / C. Geserick [and others] -- The real meaning of high expression / S.I. Grammatikos [and others] -- A novel mammalian gene regulation system responsive to streptogramin antibiotics / M. Fussenegger [and others] -- Feedback control of redox potential in hybridoma cell culture / A. Meneses, A. Gomez, O.T. Ramirez -- Genetic manipulation of the protein synthetic capacity of mammalian cells / M. Heaton [and others] -- Retinoic acid enhances monoclonal antibody production of human-human hydriboma BD9 / Y. Inoue [and others] -- Extracellular adenosine 5' monophosphate controls proliferation and stimulates protein production of rCHO cells / H.P.J. Bonarius, K. Hansen, L. Kongerslev -- The mode of actions of lysozyme as an immunoglobulin production stimulating factor (IPSF) / T. Sugahara, F. Murakami, T. Sasaki. A dissection of recombinant protein expression in CHO cells indicating protein-specific, not cell specific, limitation / K. Altobello [and others] -- Effect of bioreactor process control parameters on apoptosis and monoclonal antibody production during the protein-free fed-batch culture of a murine myeloma / E. Moran [and others] -- Adenovirus vector production in 293 fed-batch cultures / K. Wong [and others] -- Influence of BCL-2 over-expression on NS0 and CHO culture viability and chimeric antibody productivity / B.T. Tey, R.P. Singh, M. al-Rubeai -- A regulatable selective system facilitating isolation of high expression mammalian cells / K. Teruya [and others] -- Comparative analysis of IRES efficiency of dicistronic expression vectors in primary cells and permanent cell lines / L. Schumacher, P.M. Alves, M. Wirth -- Use of gel microdrops selection system for recombinant cells / K. Hansen, C. Bertelsen, L. Kongerslev. Bovine serum-albumin with grafted RGD tailed cyclic peptides as an engineered proadhesive protein / J. Dewelle [and others] -- Matrix attachment regions in stable CHO cell line development / M.M. Zahn, M. Kobr, M. Mermod -- High cell density cultivation of hydridoma cells spin filter vs. immobilized culture / H. Heine, M. Biselli, C. Wandrey -- Influence of the inoculum on the production of antibodies with mammalian cells / M. Inglin [and others] -- Establishing and developing CHO cell lines for the commercial production of human anti-rhesus D IgG / M. De Jesus [and others] -- Glucose and glutamine replacement for the enhancement of fed-batch processes using CHO cells / C. Altamirano [and others] -- Pilot scale production of human prothrombin using a recombinant CHO cell line / D. Lütkemeyer [and others] -- Maintenance of high viability during direct transition of CHO-Kl cell growth from 10% to 0% serum : no adaptation required / M.C. Tsao [and others]. Analysis and simultaneous isolation of recombinant t-PA using high performance membrane affinity chromatography / G. Renemann, G. Kretzmer, T.B. Tennikova -- Improvement of the primary metabolism of cell cultures introducing a pyruvate carboxylase reaction pathway / N. Irani [and others] -- Growth kinetic studies (in hours) based on the fluorescence of stable, GFP-expressing CHO cells / L. Hunt [and others] -- Intracellular localization of non-secreted recombinant [beta]-trace protein in vesicle-like structures of baculovirus-infected insect cells / N. Schulze [and others] -- Induction kinetics of apoptosis in mammalian cell cultures / M. Linz, A.-P. Zeng, W.-D. Deckwer -- A model for the on-line scrutiny of metabolism : its application to the changing nutritional demands of cultured animal cells / Y.H. Guan, R.B. Kemp -- Caspases as a target for apoptosis inhibition in hybridoma cells in culture / C. Gabernet [and others]. Cell activity after cell growth inhibition by the IRF-1 system / A.S. Coroadinha [and others] -- Establishment of a primary liver cell culture from a teleost, Oreochromis mossambicus, the tilapia : a valid tool for physiological studies / A.C. Schmid, W. Kloas, M. Reinecke -- TGB-[beta] induces premature and replicative senescence in cancer cells / T. Miura [and others] -- Development of a fed-batch strategy that utilized multiple carbon sources to maximize recombinant protein expression in CHO cells / F. Deer, M.R. Cunningham -- Development of a new, highly flexible, fully computer integrated fermentor control system / Büntemeyer [and others] -- Cell growth rate estimation in packed-bed and hollow fibers bioreactors : metabolism and productivity / M.T.A. Rodrigues [and others] -- Influence of oxygen limitation on myeloma cell cultures : various methods of inoculum proliferation for bioreactor cultivations / R. Spinnler [and others]. Comparison of fed-batch strategies in hybridoma cultures / J.O. Schwabe, I. WIlkens, R. Pöortner -- Non-invasive adaptive control of the feed rate for high cell density CHO cultures according to the on-line pO2 profile / D. Müller, O. Doblhoff-Dier, H. Katinger -- Cell growth control by the IRF-1 system in perfusion culture / A.V. Carvalhal, J.L. Moreira, M.J.T. Carrondo -- Modulation of cell cycle for optimal recombinant protein production / V. Hendrick [and others] -- Application of bioassays for suspended 293 cell enumerations in chemically defined medium (CDM) / M.C. Tsao [and others] -- Efficient cell growth by an optimised protein free medium design and a controlled feeding strategy / A. Loa, P. Lefebvre, G. Kretzmer -- Development of a serum free medium for a human diploid fibroblast cell line / S. Pirotton [and others] -- The use of peptones as medium additives for high-density perfusion cultures of animal cells / R. Heidemann [and others] -- Determination of animal cell densities and viability by the new analyser CEDEX2 / T. When [and others]. Determination of animal cell densities and viability : comparison of the microcyte flow cytometer with trypan blue counts and Coulter count / N. Vriezen -- Mid-infrared spectroscopic monitoring of animal cell culture bioractor processes / M. Rhiel [and others] -- Mammalian cell monitoring using the miccrocyte flow cytometer / C.L. Harding [and others] -- Indirect biomass determination in case of non-constant metabolic rates / P. Ducommun [and others] -- Whole cell -- smart microsensor : a first approach towards interfacing live cells and electronics / O. Charlier [and others] -- Comparison of immobilised group specific affinity ligands for the bioseparation of antibodies by high performance membrane affinity chromatography / L.G. Berruex, R. Freitag -- Posttranslational modifications limit high level expression of functionally active chimeric P-selectin glycoprotein ligand-1 in rCHO cells / M.S. Sinacore [and others]. Glycolsylation analysis of nanomolar amounts of glycoprotein comtining in-gel enzymatic digestion and FACE / C. Kloth [and others] -- Glycosylation patterns of a rec-fusion protein expressed in BHK cells at different metabolic states / H.J. Cruz [and others] -- Elimination of N-glycolylneuraminic acid residues in recombinant glycoproteins : a gene knock-out approach / O. Fontana [and others] -- Fucosyltransferase III production by mammalian and insect cells for the synthesis of therapeutic oligosaccharides / C. Benslimane [and others] -- Control of therapeutic monoclonal antibody glycosylation / A.E. Hills [and others] -- The effect of cell line, transfection production and reactor conditions on the glycosylation of recombinant human anti-rhesus D IgGl / S. Nahrgang [and others] -- Metabolic engineering of recombinant plasminogen sialylation in animal cells by tetracycline-regulated expression of murine CMP-NeuAc synthetase and hamster CMP-NeuAc transporter genes / K.N. Baker [and others]. Air-trap-technology : bubble-free gas transfer in large scale / M.B. Däscher, B. Sonnleitner, A. Georg -- The improvement of aeration in 8000 I animal cell culture vessels / T.M. Clayton, I. Jenkins, P. Steward -- A novel continuous suspension culture system for hematopoietic cells / S. Schmidt [and others] -- Large scale production of HIV-I gp120 using recombinant vaccinia virus in packed-bed bioreactor / J. Kaufman [and others] -- The "shear tester" : a universal tool for characterization of the shear sensitivity of animal cell lines under various process conditions / A. Flagmeyer, K. Konstantinov, H.-J. Henzler -- Membrane oxygenation of mammalian cell culture fermenters using DuPont Teflon AF-2400 tubing / J. Blackie, P. Wu, D. Naveh -- Configuration of a simple dialysis membrane bioreactor suitable for large-scale application / B. Kleuser [and others] -- Erythropoietin production from CHO cells grown in a fluidized-bed bioreactor with macroporous beads / M.D. Wang [and others]. Scale-up of fixed-bed reactors for the cultivation of animal cells / D. Fassnacht, I. Reimann, R. Pörtner -- A novel conical shaped bioreactor for small-scale investigations under defined conditions / J.O. Schwabe [and others] -- Continuous perfused fluidized bed technology : increased productivities and product concentrations / D. Müller [and others] -- Small scale bioreactor system for process development and optimization / P. Girard [and others] -- Mammalian transient gene expression-potential, practical applications and perspectives / H.D. Blasey -- Float!, and express more : converting the HEK. EBNA/oriP system to suspension culture / S. Geisse [and others] -- Multiplicity and time of infection as tools to maximize virus-like particle production by insect cells / L.A. Palomares [and others] -- Process development for transient gene expression in mammalian cells at the 3L scale : 10-50 MG of R-protein in days / P. Meissner [and others]. A method to determine the optimal time to infect insect cells with the baculovirus expression system / J. Ljunggren [and others] -- Analysis of baculovirus infected Sf9 cells using flow cytometry / G.R. Pettman -- Adaptation of recombinant HEK-293 cells to growth in serum-free suspension / R.C. McAllister [and others] -- Growth on microcarriers and nutritional needs of high density insect cell cultures / L. Ikonomou [and others] -- Use of flow cytometry in the evaluation of hydroxyapatite for the purification of DNA plasmid / J.L. Wright [and others] -- Regulation and standardisation of gene transfer products in the European Union / K. Cichutek -- Study of stability of expression of a humanized monoclonal antibody from a transfected NSO myeloma cell line using different culture media and serum concentrations / A.J. Castillo, S. Victores, I.W. Marison -- Analysis of alterations in gene expression after amplification of recombinant genes in CHO cells / O. Hohenwarter [and others]. Stable recombinant expression and functional identity of the anti HIV-I monoclonal antibody 2F5 after IGG3/IGGI subclass switch in CHO-cells / R. Kunert [and others] -- Analysis of genomic DNA and RNA-transcripts of a heterohybridoma simultaneously expressing IgG3 and IgGI with identical specificity / R. Kunert [and others] -- Tissue engineering of a bladder wall patch / I. Bisson [and others] -- Integrated optimization of retrovirus production for gene therapy / P.E. Cruz [and others] -- Toxicological evaluation of surface water samples in sensitized cultured fish cells, and comparison with the Microtox method / P.J. Dierickx, C. Van der Wielen, N. François -- Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes / M. Oda [and others] -- Study of DDS for a cancer therapy applying lipid vesicle immobilizing Eucheuma Serra lectin / K. Kato [and others]. Study of the specific binding between lipid vesicles and human-human hybridoma toward either DDS or gene transfection / K. Kato [and others] -- Suppression of apoptosis in UV-damaged human melanoma cells by a fermented milk, kefir / T. Nagira [and others] -- Large scale GMP production of retroviral gene therapy vector in very low serum medium / N. Moy [and others] -- Chimeric lyssavirus glycoprotein : new vector for multivalent vaccines / E. Desmezières [and others] -- The SPP Biotech Module 1 : proteins for medical applications : a multidisciplinary effort for the development of a recombinant anti-RhD antibody preparation of hemolytic disease of the newborn / H. Amstutz [and others] -- Low serum and serum-free cultivation of mammalian cells used for virus production applications / D.W. Jayme [and others] -- Development of a serum free mediunm for MRC-5 culture / C. Maggetto [and others]. Adaptation of vero cells to a serum free medium for the production of rabies virus / S. Majoul [and others] -- Increased productivity of a rickettsia vaccine : enhancement of adhesion properties of infected endothelial cells TGF[beta] / T. Marique [and others] -- Comparative study of cell cultures perspective for rubella virus production / T.N. Getmanova [and others] -- Biogenesis of epithelial phenotype during long-term cultivation of MDCK cells in serum-free ultra-MDCK medium / N. Kessler, G. Thomas, M. Aymard -- Sandwich Elisa today : limits for sensitivity, speed, precision and throughput / M. Jordan [and others] -- Impact of ICH guidelines on phases of development of biotechnology products / A.S. Lubiniecki -- The microbial risks of xenotransplantation / D.N. Galbraith, D.E. Onions -- Cryopreservation under protein-free medium conditions : a reliable way to safe cell banking / F. Hesse, K. Scharfenberg, Wagner. Creation of certified cell banks suitable for production of healing and immunobiological preparations / T.D. Kolokoltosva [and others] -- Endogeneous retrovirus particles and their effects on the growth behavior of hybridoma cultivation processes / A. Hawerkamp [and others] -- Testing for adventitious retroviruses using PCR-based reverse transcriptase assays / A. Lovatt [and others] -- Rapid RNA quantitation from xenotropic SP2/0 retroviruses by competitive RT-PCR ELISA / W. Hansen [and others] -- Human amniotic epithelial (HAE) cells express erythropietin (EPO) and EPO-receptor / K. Katsuura [and others] -- The nordenau-phenomenon : facts and hypotheses / Z. Gadek, J.D. Zeifert -- Conversion of a process development pilot plant into a clinical phase I/II manufacturing facility for recombinant proteins expressed in mammalian cells / T. Klamer, J.M. Petersen, R. Skovgaard. Human keratincyte culture on macroporous carriers at the air-liquid interface / E.K. Kinnau [and others] -- Comparison of viability and function of primary cells with transformed cells for use in a bioartificial liver support system / L. Wang [and others] -- Determining optimal transport conditions of in vitro cultured human chondrocytes prepared for autologous re-implantation using flow cytometry / G. Wozniak [and others] -- Effects of collagenase on human hematopoietic cells / N. Jelinek [and others] -- Validation of the CACO-2 test for intestinal permeability assessment of drugs : the usefulness of PAPP, the apparent permeability coefficient / F. Fassio [and others].
• 摘要: This book contains, in the form of concise papers of limited length, the proceedings of the 16th ESACT meeting that was held in Lugano, Switzerland, in April 1999. We hope it will become a useful resource of the most up-to-date information in animal cell technology, at least until the next meeting in 2001. Classical approaches for the use of animal cells (for example, production of virus vaccines) remain an important technology. However, it appears that major technological advances and major growth are occurring in other areas. Most importantly, protein production on the basis of recombinant DNA molecules transferred into animal cells appears to be an ever-increasing field of interest and innovation. Increasingly animal cells are being used as substrates for the study of gene activation and repression, and also for the more rapid production of small and moderate quantities of interesting proteins. Tissue engineering, somatic gene/cell therapy, organ-replacement technologies, and cell-based bio-sensors all contribute to a considerable widening of interest and research activity, based on animal cell technology.
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