附註:Includes bibliographical references and index.
Preliminaries; Contents; 1 Analysis of Glycans of Recombinant Glycoproteins; 2 The Effect of Cell Culture Parameters on Protein Glycosylation; 3 Glycosylation of Recombinant 1gC Antibodies and its relevance for Therapeutic Applications; 4 Cellular Modification for the Improvement of the Glycosylation Pathway; 5 Controlling Carbohydrates on Recombinant Glycoproteins; 6 Targeting of Genetically Engineered Glycosyltransferases to In Vivo Functional Golgi Subcompartments of Mammalian Cells.
7 A Metabolic Substrate-Based Approach to Engineering New Chemical Reactivity Into Cellular SialoglyCoconjugates8 Addressing Insect Cell Glycosylation Deficiencies through Metabolic Engineering; 9 Asparagine-Linked Glycosylational Modifications in Yeast; Index.
摘要:The analysis and modification of glycans of recombinant proteins continues to be a challenging area of research. This text provides reviews of advances in the subject and an assessment of state-of-the-art methodology and the various approaches for the improvement of glycoprotein production.
