附註:Includes bibliographical references and indexes.
Contents -- Foreword -- Preface -- General Aspects -- The Need for New Therapy -- Current Therapy for Asthma -- Current Therapy for COPD -- Pharmacogenetics -- Delivery of Biologics to the Lung -- Immunopathology: Comparison of COPD and Asthma -- Monitoring Lung Function -- Airway Hyperresponsiveness -- Airways Remodelling -- Exhaled Breath Analysis -- Clinical Studies on New Drugs -- Bronchodilators -- Bronchodilators: An Overview -- Long-Acting ß -- Agonists -- Single-Isomer ß-Agonists -- Anticholinergics: Tiotropium
Potassium Channel OpenersUrodilatin -- Steroids -- Steroids: An Overview -- Ciclesonide: An On-Site-Activated Steroid -- Soft Steroids -- Dissociated Steroids -- Oestradiol Metabolites -- Leukotriene Inhibitors -- Leukotriene Inhibitors: An Overview -- Cysteinyl Leukotriene Antagonists -- 5-Lipoxygenase Inhibitors -- LTB4 Antagonism -- Mediator Inhibitors and Agonists -- H1-Antihistamines -- Histamine H3 Antagonists -- Kinin Receptor Antagonists -- Endothelin Antagonists -- Tachykinin Antagonists -- Antioxidants -- Selective iNOS Inhibitors
Mucus RegulationP2Y Receptor Agonists -- Protease Inhibitors -- Tryptase Inhibition -- Neutrophil Elastase Inhibitors -- Macrophage Metalloelastase Inhibitors -- Allergen- and IgE-Directed Therapies -- Allergen, IgE and Mast-Cell-Directed Therapies: An Overview -- Allergen Immunotherapy -- Peptide Immunotherapy -- Recombinant Allergens -- Anti-IgE Antibody -- CD23 -- T Cell Immunomodulation -- T Cell Immunomodulation: An Overview -- Costimulatory Molecules in T Cell Activation -- GATA-3: A Th2-Selective Target -- Mycobacterial Immunization
CpG OligodeoxynucleotidesCD8 T Cells: Potential Therapeutic Targets? -- Macrocyclic Immunosuppressants -- Cytokine-Directed Therapy -- Cytokines: An Overview -- TNF Antagonism -- GM-CSF Antagonists -- Interleukin-4 Antagonism -- Interleukin- 13 Antagonism -- Interleukin-5 Antagonism -- Interleukin- 10 -- Interleukin- 12, Interleukin- 18 and Interferon- Ã? -- Chemokine Receptor Inhibition -- Chemokines: An Overview -- Chemokine Receptors on Th1 and Th2 Cells -- CCR-3 Antagonists -- Interleukin-8 Receptor (CXCR2) Antagonists
Adhesion Molecule InhibitorsAdhesion Molecule Antagonism: An Overview -- Small-Molecule VLA-4 Antagonists -- Selectin Antagonists -- ICAM- 1 and VCAM- 1 Antagonists -- Inhibition of Cell Signalling -- Eosinophil G-Protein-Coupled Receptor Signalling: An Overview -- Phosphodiesterase 4 Inhibitors -- Therapies Acting on Transcription -- Therapies Acting on Transcription: An Overview -- Chromatin Modification -- Activator Protein- 1 and Nuclear Factor- Kappa B -- Inhibition of p38 MAP Kinase -- STAT6 -- Retinoids -- Genetic Therapy
摘要:This book provides a state-of-the-art account by academic respiratory physicians and senior pharmaceutical industry personnel on the development of new drugs for asthma, allergy and COPD. It contains 80 chapters of highly condensed information, presented in an attractive, reader-friendly format with much use of tables, figures and diagrams. In addition to summarizing the diverse range of current approaches, this handbook also looks into the future, considering many topics that are promising, but have only emerged in the last few years. Developments within established drug categories such as beta-2-agonists, steroids and leukotriene antagonists are also reviewed. Never before has a single book brought together so many pharmaceutical drug developers sharing their experience on such a wide range of respiratory topics!
