3D QSAR in drug design.Vol. 2,Ligand-protein interactions and molecular similarity
- 其他作者: Kubinyi, Hugo. , Folkers, Gerd. , Martin, Yvonne Connolly,
- 出版: New York : Kluwer Academic ©2002.
- 稽核項: 1 online resource (416 pages) :illustrations (some color).
- 叢書名: QDSAR ;v. 2
- 標題: MEDICAL Pharmacology. , MEDICAL Nursing -- Pharmacology. , Drugs , MEDICAL , NursingPharmacology. , Médicaments Conception. , Médicaments , Drug Design. , Drug Design , Relations structure-activité quantitatives (Biochimie) , QSAR (Biochemistry) , Pharmacy. , MEDICAL Pharmacy. , Electronic books. , Drug Guides. , MEDICAL Drug Guides. , Conception. , Drugs Design. , Pharmacology. , Quantitative Structure-Activity Relationship , Design.
- ISBN: 0306468573 , 9780306468575
- 試查全文@TNUA:
- 附註: Includes bibliographical references and indexes.
- 摘要: Volumes 2 and 3 of the 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the highly successful first volume about four years ago. Volume 2 (Ligand-Protein Interactions and Molecular Similarity) divides into three sections dealing with Ligand-Protein Interactions, Quantum Chemical Models and Molecular Dynamics Simulations, and Pharmacophore Modelling and Molecular Similarity, respectively. Volume 3 (Recent Advances) is also divided into three sections, namely 3D QSAR Methodology: CoMFA and Related Approaches, Receptor Models and Other 3D QSAR Approaches, and 3D QSAR Applications. More than seventy distinguished scientists have contributed nearly forty reviews of their work and related research to these two volumes which are of outstanding quality and timeliness. These works present an up-to-date coverage of the latest developments in all fields of 3D QSAR.
- 電子資源: https://dbs.tnua.edu.tw/login?url=https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=76079
- 系統號: 005301101
- 資料類型: 電子書
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- 引用網址: 複製連結
Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series. 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim of that early book was to contribute to the understanding and the further application of CoMFA and related approaches and to facilitate the appropriate use of these methods. Since then, hundreds of papers have appeared using the quickly developing techniques of both 3D QSAR and computational sciences to study a broad variety of biological problems. Again the editor(s) felt that the time had come to solicit reviews on published and new viewpoints to document the state of the art of 3D QSAR in its broadest definition and to provide visions of where new techniques will emerge or new appli- tions may be found. The intention is not only to highlight new ideas but also to show the shortcomings, inaccuracies, and abuses of the methods. We hope this book will enable others to separate trivial from visionary approaches and me-too methodology from in- vative techniques. These concerns guided our choice of contributors. To our delight, our call for papers elicited a great many manuscripts.
來源: Google Book
來源: Google Book
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