附註:"This book contains contributions presented at the last of the Alcuin Symposia, held in April 2000, as a Festschrift to honour Prof. Axel Wollmer on the occasion of his retirement from the Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen"--Foreword.
Includes bibliographical references and indexes.
Cover -- Table of Contents -- Foreword -- Contributors -- How Insulin Came From Heidelberg To Aachen and Why It Took five Years -- Insulin at The German Wool Research Institute ... Retrospect and Outlook -- Insulin: Sequence, Structure and Function -- A Story of Surprises -- The Association/Dissociation equilibria of insulin in the presence of metal ions: A Fluorescence Energy Transfer and Circular Dichroism Study -- Self-association of Insulin Reconsidered I.A Scheme Based on Contact Surfaces -- Self-association of Insulin Reconsidered II. Mathematical Description -- T-R Transition -- Comparison of Conformational Transitions in Proteins -- Activities of Insulin Analogues at Position A8 are Uncorrelated with Thermodynamic Stability -- Relationships between the Structure of Insulin and its Physiological Effects -- Structure-Function Relationships of Insulin and Insulin-Like Growth Factor-I Receptor Binding -- Structural Relationships Between Members of the Insulin Receptor Family -- Insulin Interaction with Minimized Receptors and Binding Proteins -- Identification of Susceptibility Loci for Obesity, Insulin Resistance, and Hyperglycemia in a Backcross Model of New Zealand Obese (NZO) and Lean SJL MICE -- Activation Mechanism of fibroblast growth factor receptor tyrosine kinase revealed by crystal structure of fibroblast growth factor receptor ectodomain bound to fibroblast growth factor and heparin -- IL-6 type cytokine receptor complexes -- Inhibition of growth factor stimulated pathways for the treatment of prostate cancer -- Molecular Dynamics Simulations of Carbonmonoxy Myoglobin and Calculations of Heme Circular Dichroism -- Author Index.
摘要:This book comprises an overview of insulin and other peptides in the context of structure, receptor interaction and pharmacological function, presented at the last Alcuin Symposium in Aachen, Germany, held in honor of the lifetime achievements of Prof. Axel Wollmer in the structural analysis of insulin. The major achievements in structural analysis of insulin, insulin analogues, receptor interaction and signal pathways are described by outstanding scientists in this field.
