附註:Includes bibliographical references and index.
1. Phosphatidylinositol 3-kinase signalling: a tale of two kinase activities / Paul J. Coffer -- 2. Mammalian MAP kinase pathways / John M. Kyriakis -- 3. Genetic approaches to protein kinase function in lower eukaryotes / Simon E. Plyte -- 4. Specificity in JAK-STAT signalling / Adrienne Halupa and Dwayne L. Barber -- 5. On the road to destruction: suppression of protein tyrosine kinase signalling by SOCS family proteins / Robert Rottapel, Subburaj Ilangumaran and Paulo de Sepulveda -- 6. Cyclin-dependent protein kinases / Kathleen L. Gould -- 7. Mechanisms and biology of signalling by serine/threonine kinase receptors form the TGF[beta] superfamily / Michael Kluppel, Pamela A. Hoodless and Jeffrey L. Wrana / [and others] -- 8. The ATM and DNA-PK proteins: the sensing, signalling, and repair of DNA damage / Robert Bristow, Hans Bluyssen and Annelies de Klein / [and others].
摘要:Since the publication of ""Protein Kinases"" in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been advances in our understanding of the cellular functions of this diverse class of proteins. This text is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosph.
