Targeting treatment of soft tissue sarcomas

• 其他作者: Verweij, J. , Pinedo, H. M.
• 出版: Boston : Kluwer Academic Publishers ©2004.
• 稽核項: 1 online resource (184 pages) :illustrations.
• 叢書名: CTAR ;v. 120 , C>T.A.R. ;120
• 標題: HEALTH & FITNESS , methods , MEDICAL , Drug targeting. , Oncology. , Sarcoma therapy , Receptors, Growth Factor , Sarcoma physiopathology , Drug Delivery Systems methods , Antineoplastic Agents , Soft tissue tumors Treatment. , physiopathology , MEDICAL Oncology. , therapy , Electronic books. , Growth Substances , Sarcoma Treatment. , Treatment. , Drug Delivery Systems , HEALTH & FITNESS Diseases -- Cancer. , Sarcoma , Soft tissue tumors , DiseasesCancer.
• ISBN: 1402078560 , 9781402078569
• ISBN: 9781402078088 , 1402078080
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• 附註: Includes bibliographical references and index. 1. Targeted therapy : ready for prime time? / C. Seynaeve and J. Verweij -- 2. Volume-based radiotherapy targeting in soft tissue sarcoma / Iain Ward [and others] -- 3. Preoperative therapy for soft tissue sarcoma / Janice N. Cormier, Howard N. Langstein, Peter W.T. Pisters -- 4. TNF-based isolated limb perfusion : a decade of experience with antivascular therapy in the management of locally advanced extremity soft tissue sarcomas / Dirk J Grunhagen [and others] -- 5. Pitfalls in pathology of soft tissue sarcomas / Judith V.M.G. Bovee and Pancras C.W. Hogendoorn -- 6. Molecular biology and cytogenetics of soft tissue sarcomas : relevance for targeted therapies / Jonathan Fletcher -- 7. KIT and PDGF as targets / Jaap Verweij -- 8. Targeting mutant kinases in gastrointestinal stromal tumors : a paradigm for molecular therapy of other sarcomas / Mike C. Heinrich, Christopher L. Corless -- 9. Targeting other abnormal signalling pathways in sarcoma : EGFR in synovial sarcomas, PPAR-y in liposarcoma / Jean-Yves Blay [and others] -- 10. Angiogenesis : a potential target for therapy of soft tissue sarcomas / K. Hoekman and H.M. Pinedo.
• 摘要: Recent achievements in the development of new techniques and agents for the treatment of cancer in general as well as for soft tissue sarcomas are tremendous. Molecular biology research has changed the landscape considerably and an increasing number of subtypes of soft tissue sarcomas are related to changes in cellular growth factors in the cell signaling pathways. This enables the development of targeted agents with specific activity against these factors. The presence of the KIT receptor at the surface of the gastrointestinal stroma tumor cell, and the activation constituted by mutations has.
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• 系統號: 005309361
• 資料類型: 電子書
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• 引用網址: 複製連結
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