附註:Includes index.
Historical Milestones -- Discovery of Ghrelin, an Endogenous Ligand for the Growth -- Hormone Secretagogue Receptor -- Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands -- A New Link Between the Neuroendocrine Control of the GH Axis, Food Intake and Sleep -- Growth Hormone Releasing Activity of Ghrelin -- Non-Growth Hormone Endocrine Actions of Ghrelin -- Ghrelin Food Intake and Energy Balance -- Cardiovascular Activities of Ghrelin and Synthetic GHS -- Central Actions and Potential Implications in Neuro-Degenerative Diseases -- Ghrelin and Tumors -- Metabolic Actions of Ghrelin -- Gastro-Entero-Pancreatic Actions of Ghrelin -- A New Interaction to Come: Ghrelin and Steroid Hormones -- Circulating Ghrelin Levels in Pathophysiological Conditions -- Ghrelin Measurement: Present and Perspectives -- Ghrelin: Implications in Pediatric Endocrinology -- Ghrelin and its Analogues: Perspectives for a Story of Reverse Pharmacology -- Index.
Includes bibliographical references and index.
摘要:Ghrelin is a 28-amino acid acylated peptide predominantly produced by the stomach. It displays strong GH-releasing activity mediated by the hypothalamus-pituitary GH secretagogue (GHS)-receptors specific for synthetic GHS. Ghrelin also acts on other central and peripheral receptors and enables other actions including: stimulation of lactotroph and corticotroph secretion; food-intake; gastro-entero-pancreatic functions; metabolic; cardiovascular activity; and anti-proliferative effects. This volume aims to highlight the impact and function of the hormone ghrelin and provide insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.
