The complement system :novel roles in health and disease

• 其他作者: Szebeni, János,
• 出版: Boston : Kluwer Academic Publishers ©2004.
• 稽核項: 1 online resource (xxi, 565 pages) :illustrations.
• 標題: Receptors, Complement , MEDICAL , Immunology. , MEDICAL Immunology. , Electronic books. , Complement (Immunology) , Immunity , Complement System Proteins
• ISBN: 1402080557 , 9781402080555
• ISBN: 1402080557
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• 附註: Includes bibliographical references and index. Part 1. A Piece of Complement History -- 1. The Development of the "One-Hit" or "Single Site" Theory of Complement Mediated Immune Hemolysis : A Personal Account / T. Borsos -- Part 2. Pathways, Genetics and Gene Regulation of Complement -- 2. The Initiation Complexes of the Classical and Lectin Pathways / P. Gal [and others] -- Complement Genetics / Gy. Abel and V. Agnello -- Regulation of Complement Receptor Gene Expression : Regulators and Inhibitors / M. Tolnay and G.C. Tsokos -- Part 3. Novel Regulatory Roles of Complement in Health and Disease -- 5. Coordination of Adaptive Immune Responses by C3 / A. Erdei [and others] -- 6. Terminal Complement Complex : Regulation of Formation and Pathophysiological Functions / F. Tedesco, R. Bulla and F. Fischetti -- 7. The Many Faces of the Membrane Regulators of Complement / C.L. Harris and B.P. Morgan -- 8. New Insights Into the Regulation of Complement Activation by Decay Accelerating Factor / L. Kuttner-Kondo and E.M. Medof -- 9. The Role of Complement in Pregnancy and Fetal Loss / G. Girardi and J.E. Salmon -- 10. Complement Deficiencies : a 2004 Update / Gy. Abel and V. Agnello -- Part 4. Exploitation of Complement Proteins in Infection and Cancer -- 11. Microbial Evasion Mechanisms Against Human Complement / R. Wurzner and P.F. Zipfel -- 12. Complement-Mediated Antibody-Dependent Enhancement of Viral Infections / Z. Prohaszka [and others] -- 13. Tumor Cell Resistance to Complement-Mediated Lysis / M. Kirschfink and Z. Fishelson -- Part 5. Role of Complement in Autoimmune Diseases, Allergy and Transplantation -- 14. Complement and Autoimmunity / G.C. Tsokos and M. Tolnay -- 15. The Complex Roles of Anaphylatoxins in Allergic Asthma and Autoimmune Diseases / H. Hawlisch [and others] -- 16. Role of Complement in Allergy / L. Varga, H. Farkas and G. Fust -- 17. Complement Activation-Related Pseudoallergy : Mechanism of Anaphylactoid Reactions to Radiocontrast Media and Drug Carrier Liposomes and Micelles / J. Szebeni
• 摘要: The Complement System: Novel Roles in Health and Disease surveys the advances in basic and applied research on the complement system over the past few years. Complement is a major protein network in blood that has been traditionally conceived as part of the immune system, a proinflammatory cascade engaged in nonspecific antimicrobial defence. However, it became clear recently that this system also plays an essential role in specific, adaptive immune responses, as well as in many basic physiological processes including cardiovascular regulation, pregnancy and tissue regeneration, just to mention a few. Complement proteins are widely involved in the immune evasion tactics of infectious microbes and cancer cells, and derangement of complement function contributes to numerous autoimmune, allergic and acute catastrophic diseases. Because pharmacological manipulation of the complement system provides therapeutic benefit in many of these conditions, we may be very close to widespread clinical use of a new class of drugs influencing complement activation or action. In fact, complementology may be one of the most versatile and dynamic subdisciplines in medicine today. The 25 reviews of this volume, written by prominent experts, provide state-of-art insights into the various aspects of an amazing progress in this field.
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• 系統號: 005312154
• 資料類型: 電子書
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