附註:Committee chairmen: Robert N. Butler and Emil A. Pfitzer.
Includes bibliographical references (pages 171-208).
AGING In Today's Environment; Copyright; Preface; Contents; Executive Summary; AGING AND NUTRITION; AGING AND SUSCEPTIBILITY TO DISEASE; AGING, DISEASE, PHARMACEUTICAL USE, AND CHEMICAL RESPONSE; AGING AND ENVIRONMENTAL FACTORS; MODEL SYSTEMS FOR RESEARCH; CONCLUSIONS; 1 Aging and Environmental Exposure ; BASIS OF THE SCIENTIFIC PROBLEM; STRUCTURE OF THE REPORT; 2 The Aging Population and the Psychosocial Implications of Aging ; DEMOGRAPHIC CONSIDERATIONS OF AN AGING POPULATION; PSYCHOSOCIAL ENVIRONMENT; 3 Principles of Gerontology ; CONCEPTUAL CONTEXT OF GERONTOLOGY; THEORIES OF AGING.
Deterministic TheoriesDevelopmental Switches in Gene Expression; Neuroendocrine-Cascade Theories; Stochastic Theories; Intrinsic Mutagenesis Theory; Protein-Synthesis Error Catastrophe; Free Radicals; Posttranslational Glycation of Proteins and DNA; Thymic Involution as a Pacemaker of Immunosenescence; BIOMARKERS OF AGE OR AGING; ALTERED SUSCEPTIBILITY OF THE AGED; 4 Principles of Toxicology in the Context of Aging ; CHEMICAL FATE AND EFFECT; Absorption; Distribution; Metabolism and Elimination; MECHANISMS OF TOXICITY AT THE MOLECULAR, CELLULAR, AND TISSUE LEVEL; Molecular Action.
Cellular EffectsEffects at the Tissue Level; PHARMACOGENETICS; BIOLOGIC MARKERS; TOXICITY TESTING; 5 Characteristics of the Environment, Aging, and the Aged ; NUTRITION; Effects of Nutrition on Toxicity; Nutrition and Cancer; Nutrition and Aging; Background and Criteria for Evaluating Aging; Food Restriction; Dietary Protein Intake; Dietary Fat Intake; Dietary Carbohydrate Intake; Dietary Vitamin Intake; Dietary Mineral Intake; Special Dietary Requirements of the Aged; PHARMACEUTICALS; Demographic Considerations; Patterns of Drug Use and Drug Prescribing; Ambulatory Populations.
Hospital PopulationsLong-Term-Care Facilities; Medication Compliance in the Elderly; Adverse Drug Reactions; LIFE-STYLE; Deliberate Chemical Exposure; Learned Helplessness; Atrophy of Disuse; Indoor Pollutants; Temperature; Radon; Formaldehyde; Combustion Products; Asbestos; Environmental Tobacco Smoke; Pesticides; 6 Environmental Effects on Age-Associated Diseases and Changes in Organ Function ; DEMOGRAPHICS OF AGE-ASSOCIATED DISEASES; SKIN; VISION; Cataracts; Glaucoma; Diabetic Retinopathy; Aging-Related Macular Degeneration; HEARING; NERVOUS SYSTEM; Changes Associated with Aging.
Induced Disorders and DiseasesNeurotoxicants; RESPIRATORY SYSTEM; CARDIOVASCULAR SYSTEM; RENAL SYSTEM; IMMUNE SYSTEM; SEXUALITY; ROLE OF ENVIRONMENT IN BONE METABOLISM AND VITAMIN D NUTRITION; 7 Model Systems for the Evaluation of Toxic Agents Affecting Aging or Age-Related Diseases ; CONSIDERATIONS IN CHOOSING AND DESIGNING MODEL SYSTEMS; EXAMPLES OF MODEL SYSTEMS; In Vitro Models; Nonmammalian Animal [Models; Mammalian Models; Epidemiologic Models; LIFE-SPAN MODULATION BY DRUG TREATMENT; 8 Conclusions ; 9 Recommendations ; RESEARCH; EDUCATION; FUNDING AND RESOURCES; References.
