附註:Includes bibliographical references and index.
The Architecture of the Heart: Myocyte Organization and the Cardiac Extracellular Matrix; Extracellular Matrix and Cardiac Remodeling; Pro-Inflammatory Cytokines and Cardiac Extracellular Matrix: Regulation of Fibroblast Phenotype; Pharmacology of G-Protein-linked Signaling in Cardiac Fibroblasts; Serum Markers of Fibrillar Collagen Metabolism in Cardiac Diseases; Ultrasonic Characterization of the Myocardium; The Mechanics of the Fibrosed/Remodeled Heart; Renin Angiotensin Aldosterone System and Cardiac Extracellular Matrix; Matrix Metalloproteinases and Myocardial Remodeling; Cardiac Mast Cells as Mediators of Ventricular RemodelingTurmoil in the Cardiac Myocyte: Acute Intracellular Activation of Matrix Metalloproteinases; Regulation of Cardiac Extracellular Matrix Remodeling Following Myocardial Infarction.; Experimental Models of MMP Activation: Ventricular Volume Overload; Targets for Pharmacological Modulation of Cardiac Fibrosis; Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium; Molecular Strategies for the Prevention of Cardiac Fibrosis; Prospects for Gene Therapy for the Fibrosed Heart: Targeting Regulators of Extracellular Matrix Turnover; Therapeutic Potential of TIMPs in Heart Failure.
摘要:"Interstitial Fibrosis in Heart Failure provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis." "This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment."--Jacket.
