附註:"Single topic volume."
Papers presented at the 6th International Symposium on Chromosome Aberrations held at the University of Duisberg-Essen, Germany (10th to 13th September, 2003) and a collection invited papers are included.
Includes bibliographical references and index.
Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations / Pfeiffer P [and others] -- Mechanisms of DNA double strand break repair and chromosome aberration formation / Iliakis G [and others] -- The role of homologous recombination repair in the formation of chromosome aberrations / Griffin CS, Thacker J -- Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks / Sasaki MS [and others] -- Repair rates of R-band, G-band and C-band DNA in murine and human cultured cells / Sanders MH [and others] -- On the nature of visible chromosomal gaps and breaks / Savage JRK -- Molecular targets and mechanisms in formation of chromosomal aberrations : contributions of Soviet scientists / Belyaev I -- Progress towards understanding the nature of chromatid breakage / Bryant PE, Gray LJ, Peresse N -- Human-hamster hybrid cells used as models to investigate species-specific factors modulating the efficiency of repair of UV-induced DNA damage / Marcon F, Boei JJWA, Natarajan AT -- Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations : a long road traveled and still a far way to go / Kaina B -- Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation / Pirzio LM [and others] -- Mechanisms of formation of chromosomal aberrations : insights from studies with DNA repair-deficient cells / Palitti F -- In situ DNAse I sensitivity assay indicates DNA conformation differences between CHO cells and the radiation-sensitive CHO mutant IRS-20 / Maranon DG, Laudicina AO, Muhlmann M -- DNA damage processing and aberration formation in plants / Schubert I [and others] -- DNA and telomeres : beginnings and endings / Bailey SM, Goodwin EH -- DNA repair factors and telomere-chromosome integrity in mammalian cells / Hande MP -- Interstitial telomeric repeats are not preferentially involved in rad
摘要:The role of chromosome aberrations in evolution and human health is well recognized. This volume brings together papers summarizing our current knowlege of the structure of interphase nuclei, chromosome structure, mechanisms of aberration formation and the practical application of this knowledge in radiobiology, biomonitoring of human populations and cancer research. Molecular cytogenetic techniques such as fluorescence in situ hybridization using whole chromosome and region specific painting DNA probes have been successfully used to identify and quantify chromosome aberrations, which is reflected in several papers of this volume. The mechanisms of chromosome aberration formation by different types of ionizing radiation are considered in detail. Furthermore, the important role of telomeres in maintaining chromosome integrity and their involvement in genomic instability are discussed. A final section is dedicated to the clinical relevance of chromosome aberrations in human hereditary diseases, e.g. Fanconi anemia or ataxia telangiectasia, and in many human cancers characterized by specific translocations or deletions. The study of chromosome aberrations is of great relevance in clinical genetics and oncology for diagnosis and disease prevention. Thus this publication is recommended reading for cytogeneticists, radiobiologists, oncologists, and post-graduate students of genetics and medicine.
