附註:Includes bibliographical references and indexes.
Preface / Matschinsky, F.M.; Magnuson, M.A. -- Chapter 1. Background -- Glucokinase as a Glucose Sensor : Past, Present and Future / Magnuson, M.A.; Matschinsky, F.M. -- The Hexokinase Gene Family / Wilson, J.E. -- Comparative Biochemistry of Glucokinase / Cardenas, M.L. -- Chapter 2. Human Biomedical Studies -- Maturity Onset Diabetes of the Young Type 2 / Velho, G. [and others] -- Permanent Neonatal Diabetes mellitus due to Glucokinase Deficiency / Njolstad, P.R. [and others] -- Glucokinase-Linked Hypoglycemia : Clinical Aspects of Activating Glucokinase Mutations / Christesen, H.B.T. [and others] -- Glucokinase and the Regulation of Blood Sugar : A Mathematical Model Predicts the Threshold for Glucose Stimulated Insulin Release for GCK Gene Mutations that Cause Hyper- and Hypoglycemia / Gloyn, A.L. [and others] -- Glucokinase/Glutamate Dehydrogenase Interactions in the GDH form of Congenital Hyperinsulinism / Kelley, A.; Li, C.; Stanley, C.A. -- Chapter 3. Structure and Function -- Glucokinase : A Monomeric Enzyme with Positive Cooperativity / Cornish-Bowden, A.; Cardenas, M.L. -- Molecular Models of Human Glucokinase and the Implications for Glycemic Diseases / Harrison, R.W.; Weber, I.T. -- Crystal Structure of Human Liver Glucokinase Bound to a Small Molecule Allosteric Activator : Insights into the Activating Mutations / Dunten, P. [and others] -- Chapter 4. Regulation of Glucokinase -- Molecular Biology of Glucokinase Regulation / Iynedjian, P.B. -- Role of the Transcription Factor Sterol Regulatory Element Binding Protein-1c in Hepatic Glucokinase Gene Regulation / Foufelle, F.; Ferre, P. -- Regulation of Hepatic Glucokinase Gene Expression / Postic, C.; Decaux, J.-F.; Girard, J. -- Discovery and Role of Glucokinase Regulatory Protein / van Schaftingen, E.; Veiga da Cunha, M. -- GKRP/GK: Control of Metabolic Fluxes in Hepatocytes / Agius, L. [and others] -- Regulation of Glucokinase as Islets Adapt to Pregnancy / Sorenson, R.L.; Weinhaus, A.J.; Brelje, T
摘要:The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus.The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the enzymology, structure and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that discuss the diverse roles of the enzyme in a variety of tissues. Finally, the book contains the latest information on the recently discovered class of weight drugs that activate glucokinase (i.e. glucokinase activators or GKAs).This volume is of great interest to basic and clinical diabetes researchers, geneticists, biochemists, physiologists and pharmacologists.
