Zinc finger proteins :from atomic contact to cellular function
- 其他作者: Iuchi, Shiro. , Kuldell, Natalie.
- 出版: Georgetown, Tex. :New York : Landes Bioscience ;Kluwer Academic/Plenum Publishers ©2005.
- 稽核項: 1 online resource (1 volume) :illustrations.
- 叢書名: Molecular biology intelligence unit
- 標題: physiology. , Biomédecine. , Zinc Fingers , Life SciencesGenetics & Genomics. , SCIENCE , Zinc Fingers physiology. , Zinc-finger proteins. , Sciences de la vie. , SCIENCE Life Sciences -- Genetics & Genomics. , Electronic books.
- ISBN: 0306482290 , 9780306482298
- 試查全文@TNUA:
- 附註: Includes bibliographical references and index. The discovery of zinc fingers and their practical applications in gene regulation : a personal account / Aaron Klug -- C2H2 zinc fingers as DNA binding domains / Shiro Iuchi -- TFIIIA : a sophisticated zinc finger protein / Raymond S. Brown and Jane Flint -- GAGA : structural basis for single Cys2His2 zinc finger-DNA interaction / G. Marius Clore and James G. Omichinski -- The DNA-binding domain of GATA transcription factors : a prototypical Type IV Cys2-Cys2 zinc finger / Angela M. Gronenborn -- MutM : single C2C2 zinc finger-DNA interaction / Ryoji Masui, Noriko Nakagawa, and Seiki Kuramitsu -- Homing endonuclease I-TevI : an atypical zinc finger with a novel function / Patrick Van Roey, Marlene Belfort, and Victoria Derbyshire -- Zinc finger interactions with metals and other small molecules / Jay S. Hanas, Jason L. Larabee, and James R. Hocker -- Synthetic zinc finger transcription factors / Nicoletta Corbi, Valentina Libri, and Claudio Passananti -- TFIIA and p43 : binding to 5S ribosomal RNA / Paul J. Romaniuk -- RNA binding by single zinc fingers / Martyn K. Darby -- Wig-1, a p53-induced zinc finger protein that binds double stranded RNA / Cristina Mendez-Vidal [and others]. Tandem CCCH zinc finger proteins in mRNA binding / Perry J. Blackshear, Ruth S. Phillips, and Wi S. Lai -- Ribosomal zinc finger proteins : the structure and the function of yeast YL37a / John Dresios, Yuen-Ling Chan, and Ira G. Wool -- LIM domain and its binding to target proteins / Algirdas Velyvis and Jun Qin -- Ring finger-B box-coiled coil (RBCC) proteins as ubiquitin ligase in the control of protein degradation and gene regulation / Kazuhiro Ikeda, Satoshi Inoue, and Masami Muramatsu -- Structure and function of the CBP/p300 TAZ domains / Roberto N. De Guzman [and others] -- A zinc ribbon motif is essential for the formation of functional tetrameric protein kinase CK2 / Odile Filhol, Maria Jose Benitez, and Claude Cochet -- The FYVE finger : a phosphoinositide binding domain / Harald Stenmark -- The BTB domain zinc finger proteins / Gilbert G. Prive [and others] -- KRAB zinc finger proteins : a family of repressors mediating heterochromatin-associated gene silencing / Shiro Iuchi -- The superfamily of SCAN domain containing zinc finger transcription factors / Tucker Collins and Tara L. Sander -- SP1 and Huntington's disease / Dimitri Krainc -- The role of WT1 in development and disease / Sean Bong Lee, Hongjie Li, and Ho-Shik Kim. Yin yang 1 / Huifei Liu and Yang Shi -- The multiple cellular functions of TFIIIA / Natalie Kuldell -- The role of the Ikaros gene family in lymphocyte development / Pablo Gomez-del Arco [and others] -- Basonuclin : a zinc finger protein of epithelial cells and reproductive germ cells / Howard Green and Hung Tseng -- ZAS zinc finger proteins : the other kB-binding protein family / Carl E. Allen and Lai-Chu Wu -- Role of GATA factors in development / Marc Haenlin and Lucas Waltzer -- The androgen receptor and spinal and bulbar muscular atrophy / F. Piccioni, C.J. Sumner, and Kenneth H. Fischbeck -- The role of XPA in DNA repair / Takahisa Ikegami and Masahiro Shirakawa -- MOF, an acetyl transferase involved in dosage compensation in drosophila, uses a CCHS finger for substrate recognition / Asifa Akhtar and Peter B. Becker -- MDM2 : ring finger protein and regulator of p53 / Liqing Wu and Carl G. Maki -- The zip family of zinc transporters / David J. Eide -- Apoptosis by zinc deficiency / Kirsteen H. Maclean.
- 摘要: Assembling information about various zinc finger proteins belonging to several families, this book describes features of zinc finger proteins at levels ranging from atomic to cellular and to organismal. Aimed at students as well as scientists, it addresses significance of zinc itself and the important domains often associated with zinc fingers.
- 電子資源: https://dbs.tnua.edu.tw/login?url=https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=125902
- 系統號: 005314094
- 資料類型: 電子書
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- 引用網址: 複製連結
In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.
來源: Google Book
來源: Google Book
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