附註:Includes bibliographical references and index.
1. Development of Parathyroid Glands / Thomas Gunther and Gerard Karsenty -- 2. Parathyroid Hormone, from Gene to Protein / Osnat Bell, Justin Silver and Tally Naveh-Many -- 3. Toward an Understanding of Human Parathyroid Hormone Structure and Function / Lei Jin, Armen H. Tashjian, Jr., and Faming Zhang -- 4. The Calcium Sensing Receptor / Shozo Yano and Edward M. Brown -- 5. Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate / Rachel Kilav, Justin Silver and Tally Naveh-Many -- 6. In Silico Analysis of Regulatory Sequences in Human Parathyroid Hormone Gene / Alexander Kel, Maurice Scheer and Hubert Mayer -- 7. Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D / Tally Naveh-Many and Justin Silver -- 8. Vitamin D Analogs for the Treatment of Secondary Hyperparathyrodism in Chronic Renal Failure / Alex J. Brown -- 9. Parathyroid Gland Hyperplasia in Renal Failure / Adriana S. Dusso, Mario Cozzolino and Eduardo Slatopolsky -- 10. Molecular Mechanisms in Parathyroid Tumorigenesis / Eitan Friedman -- 11. Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism / Trisha M. Shattuck, Sanjay M. Mallya and Andrew Arnold -- 12. Genetic Causes of Hypoparathyroidism / Rachel I. Gafni and Michael A. Levine -- 13. Skeletal and Reproductive Abnormalities in Pth-Null Mice / Dengshun Miao [and others].
摘要:Aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
