附註:Includes bibliographical references and index.
1. Ca2+ Chemistry, Storage and Transport in Biologic Systems : An Overview / Tashi G. Kinjo and Paul P.M. Schnetkamp -- 2. Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators / Sean J. Mulligan and Brian A. MacVicar -- 3. A Brief History of Calcium Channel Discovery / Richard W. Tsien and Curtis F. Barrett -- 4. Biochemical Studies of Voltage-Gated Ca2+ Channels / William A. Catterall -- 5. Molecular Properties of Voltage-Gated Calcium Channels / Terrance P. Snutch [and others] -- 6. Role of b Subunits in Voltage-Gated Calcium Channel Functions / Thierry Cens [and others] -- 7. Distribution and Targeting Mechanisms of Voltage Activated Ca2+ Channels / Stefan Herlitze and Melanie D. Mark -- 8. The Calcium Channel and the Transmitter Release Site / Elise F. Stanley and Allen W. Chan -- 9. Determinants of G Protein Inhibition of Presynaptic Calcium Channels / Aparna Nirdosh and Gerald W. Zamponi -- 10. Phosphorylation-Dependent Regulation of Voltage-Gated Ca2+ Channels / Roger A. Bannister, Ulises Meza and Brett A. Adams -- 11. Ca2+-Dependent Modulation of Voltage-Gated Ca2+ Channels / Amy Lee and William A. Catterall -- 12. Voltage-Dependent Inactivation of Voltage Gated Calcium Channels / Mary T. An and Gerald W. Zamponi -- 13. Selective Permeability of Voltage-Gated Calcium Channels / William A. Sather -- 14. The Run-Down Phenomenon of Ca2+ Channels / Klaus JF Kepplinger and Christoph Romanin -- 15. Calcium Channels As Therapeutic Targets / Francesco Belardetti and Sian Spacey -- 16. Calcium Channelopathies / Nancy M. Lorenzon and Kurt G. Beam -- 17. The Molecular Basis of Ca2+ Antagonist Drug Action : Recent Developments / Jurg Striessnig [and others] -- 18. Calcium Channel Block and Inactivation : Insights from Structure-Activity Studies / Steffen Hering [and others] -- 19. Block of Voltage-Gated Calcium Channels by Peptide Toxins / Christina I. Schroeder, Richard J. Lewis and David J. Adams -- 20. Calcium Channels in the Heart / Stephanie
摘要:Oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar macological targets in the treatment of a variety of disorders, such as epi lepsy, hypertension, and pain. Voltage-gated calcium channels have there fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac tivity, the book delves into a provocative overview of the history of the cal cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat ing, permeation, modulation and interactions with members of the exo- totic machinery--contributed by both established leaders and rising stars in the field.
