DNA methylation and cancer therapy
- 其他作者: Szyf, Moshe.
- 出版: Georgetown, Tex. :New York, N.Y. : Landes Bioscience/Eurekah.com ;Kluwer Academic/Plenum ©2004.
- 稽核項: 1 online resource (1 volume).
- 叢書名: Medical intelligence unit
- 標題: Neoplasms genetics , Biomédecine. , DNA Methylation. , HEALTH & FITNESS , MEDICAL , Cancer Traitement. , Cancer Treatment. , Traitement. , ADN Méthylation. , Oncology. , therapy. , Neoplasms therapy , Treatment. , genetics. , genetics , Sciences de la vie. , Neoplasms genetics. , DNA , Methylation. , MEDICAL Oncology. , therapy , Electronic books. , ADN , Cancer , Aspect moléculaire. , Cancer Aspect moléculaire. , Neoplasms , Neoplasms therapy. , DNA Methylation , HEALTH & FITNESS Diseases -- Cancer. , Molecular aspects. , Méthylation. , Cancer Molecular aspects. , DiseasesCancer.
- ISBN: 030647848X , 9780306478482
- 試查全文@TNUA:
- 附註: Includes bibliographical references and index. DNA methylation : three decades in search of function / Aharon Razin -- Epigenetic mechanisms of gene regulation : relationships between DNA methylation, histone modification, and chromatin structure / Keith D. Robertson -- DNA hypo- vs. hypermethylation in cancer : tumor specificity, tumor progression, and therapeutic implications / Melanie Ehrlich and Guanchao Jiang -- DNA methylation in urological cancers / Wolfgang A. Schulz and Hans-Helge Seifert -- DNA methylation in colorectal cancer / Jeremy R. Jass [and others] -- CpG island hypermethylation of tumor suppressor genes in human cancer : concepts, methodologies and uses / Michel Herranz and Manel Esteller -- The loss of methyl groups in DNA of tumor cells and tissues : the immunochemical approach / Alain Niveleau [and others] -- Identifying clinicopathological association of DNA hypermethylation in cancers using CpG island microarrays / Susan H. Wei [and others] -- Methylation analysis in cancer : (epi)genomic fast track from discovery to clinical routine / Carolina Haefliger, Sabine Maier and Alexander Olek. Regulation of DNA methyltransferases in cancer / Nancy Detich and Moshe Szyf -- Inhibition of poly(ADP-ribosyl)ation allows DNA hypermethylation / Anna Reale [and others] -- The role of active demethylation in cancer and its therapeutic potential / Moshe Szyf [and others] -- Purine analogues and their role in methylation and cancer chemotherapy / Katherine L. Seley and Sylvester L. Mosley -- DNA methyltransferase inhibitors : paving the way for epigenetic cancer therapeutics / Gregory K. Reid and A. Robert MacLeod -- Preclinical and clinical studies on 5-aza-2'-deoxycytidine, a potent inhibitor of DNA methylation, in cancer therapy / Richard L. Momparler -- Anticancer gene therapy by in vivo DNA electrotransfer of MBD2 antisense / Pascal Bigey and Daniel Scherman.
- 摘要: Provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This volume focuses on cancer therapy by dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. It is useful for oncologists, researchers, clinicians, and graduate students.
- 電子資源: https://dbs.tnua.edu.tw/login?url=https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=125907
- 系統號: 005314214
- 資料類型: 電子書
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NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
來源: Google Book
來源: Google Book
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