附註:Includes bibliographical references and index.
Cover -- Table of Contents -- Dedication -- Acknowledgements -- Preface -- Participants -- Symposium Address Hormones, Centrosomes, and Genetic Instability in Mammary Carcinogenesis -- STATE OF THE ART LECTURES -- 1 Chromosomal Instability: A New Paradigm for Estrogen-induced Oncogenesis -- 2 The Molecular Pathogenesis of Human Prostate Cancer -- PART 1. BREAST CANCER I: PROGESTERONE ACTION -- 3 Pathologic, Clinical, and Epidemiologic Characteristics of Invasive Lobular Breast Carcinoma and a Review of Studies Evaluating its Association with Hormone Replacement Therapy -- 4 Progestin-Regulated Genes and Breast Cancer Risk: Good or Bad? -- 5 Role of Progesterone Receptors in Mammary Development and Carcinogenesis -- PART 2. BREAST CANCER II: MECHANISMS OF GENOMIC INSTABILITY -- 6 C-Myc Deregulation Promotes a Complex Network of Genomic Instability -- 7 Deregulation of Cyclin E and Genomic Instability -- 8 Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer -- PART 3. BREAST & PROSTATE: EARLY IN-SITU LESIONS -- 9 Premalignant Breast Disease: Anatomic Lesions and Hormonal Associations -- 10 Aromatase Overexpression: Effect of Tissue Estrogen on Phenotypic and Biochemical Changes in Aromatase Transgenic Mice -- 11 Prostate Epithelial Carcinogenesis: Putative and Controversial Precursor Lesions -- PART 4. PROMOTION/PREVENTION OF HORMONE CANCERS -- 12 Estrogen Can Prevent Breast Cancer by Mimicking the Protective Effect of Pregnancy -- 13 Aromatase Inhibition and Breast Cancer -- PART 5. PROSTATE I: ANDROGEN/ESTROGEN ACTION -- 14 Androgens and Prostate Cancer Etiology: Sorting Through the Evidence -- 15 Id-1 Protein as a New Marker for Prostate Cancer -- PART 6. PROSTATE II: ANDROGEN RECEPTOR: DEPENDENCE/RESISTANCE -- 16 Four Stages of Prostate Cancer: Suppression and Eradication by Androgen and Green Tea Epigallocatechin Gallate -- 17 Androgen Receptor and Interleukin-6 Signaling in Prostate Cancer Progression -- 18 Role of the Androgen
摘要:Uniquely, Hormonal Carcinogenesis IV, integrates salient aspects of hormone-related cancers of interest to epidemiologists, basic researchers, and clinicians. The most recent advances in the major hormone-related cancers are presented by leaders of their specialty. The chapters in this volume deal with the causation, dependence, and resistance of endocrine-related cancers with particular emphasis on the most common neoplasms occuring in men and woman world wide, such as breast, prostate, uterine, and ovarian cancers.
