附註:Includes bibliographical references and index.
The woodchuck: a model for immunopathogenesis and therapy of hepadnaviral infection / Roggendorf, M., Lu, M. -- Pathogenesis of hepatitis B virus in transgenic mice / Sitia, G. [and others] -- Transfer of HBV genomes into mice / Oberwinkler, H. [and others] -- Recent advances in the duck hepatitis B virus model of human hepatitis B virus infection / Jilbert, A.R. -- Determinants of hepadnaviral species and liver cell tropism / Funk, A. [and others] -- T-cell response to hepatitis B virus and hepatitis C virus: lessons learned from the chimpanzee model / Thimme, R. [and others] -- The replicon system as an efficient tool to study HCV RNA replication / Lohmann, V. -- Hepatitis B virus infection of primary tupaia hepatocytes / Kück, J., Glebe, D. -- Tupaia belangeri as a model for hepatitis C virus infection / Baumert, T. [and others] -- Primary human hepatocytes as an in vitro model for hepatitis B virus infection / Boehm, S. [and others] -- Progress and perspectives of the uPA/RAG-2 mouse model: liver repopulation and viral infection studies / Dandri, M. [and others] -- The trimera mouse model of HBV and HCV infection / Bücher, W.O., Reisner, Y.
摘要:Viral hepatitis B or C is the most common cause of chronic liver disease worldwide and accounts for about 80% of all hepatocellular carcinoma cases. Thus, combating viral hepatitis remains one of the most pressing public health issues today. Animal models and cell-based systems are essential tools for addressing the many still unresolved basic and clinical problems. Experimental models are needed to better understand the viral life cycles, pathogenetic aspects and natural defense mechanisms, while preclinical models are required for evaluating novel preemptive and therapeutic strategies. This.
