附註:"Reprinted from the Proceedings of the National Academy of Sciences of the United States of America, volume 98, pp. 10994-11068, September 25, 2001."
Includes bibliographical references.
""Neural Signaling""; ""Arthur M. Sackler, M.D.""; ""Contents""; ""Arthur M. Sackler COLLOQUIA OF THE NATIONAL ACADEMY OF SCIENCES""; ""Introduction""; ""ARTHUR M. SACKLER AND SCIENCE""; ""Colloquium""; ""Neural roles for heme oxygenase: Contrasts to nitric oxide synthase""; ""PHYSIOLOGIC ROLES""; ""PATHOPHYSIOLOGY""; ""Presynaptic kainate receptors at hippocampal mossy fiber synapses""; ""EARLY STUDIES ON THE LOCALIZATION OF KARS""; ""KARS DIRECTLY DEPOLARIZE MOSSY FIBERS""; ""SYNAPTICALLY RELEASED GLUTAMATE ACTIVATES PRESYNAPTIC KARS""
""KAINATE HAS BIPHASIC EFFECTS ON MOSSY FIBER SYNAPTIC TRANSMISSION""""PRESYNAPTIC KARS CONTRIBUTE TO MOSSY FIBER SHORT-TERM PLASTICITY""; ""KARS MAY BE INVOLVED IN MOSSY FIBER LONG-TERM POTENTIATION (LTP)""; ""CONCLUSIONS""; ""Retrograde signaling at central synapses""; ""RETROGRADE SIGNALING DURING SYNAPTOGENESIS""; ""RETROGRADE SIGNALING IN ACTIVITY-DEPENDENT SYNAPTIC PLASTICITY""; ""CONCLUDING REMARKS""; ""Controlling potassium channel activities: Interplay between the membrane and intracellular factors""; ""T1: A MULTIFUNCTIONAL DOMAIN OF KV CHANNELS?""
""VALINE SUBSTITUTION FOR A BURIED THREONINE AT THE T1 INTERFACE STABILIZES THE CLOSED CHANNEL WITHOUT ALTERING THE SURFACE OF�""""FUNCTIONAL STUDIES OF INWARDLY RECTIFYING POTASSIUM CHANNELS IN YEAST""; ""DNA SHUFFLING, YEAST SCREENS, AND IN VITRO BACKCROSSES TO ISOLATE GIRK2 GATING MUTANTS""; ""PATTERNS OF TOLERANCE FOR AMINO ACID SUBSTITUTIONS INDICATE THAT BOTH S177 AND V188 OF THE M2 HELIX FACE THE WATER-FILLED�""; ""YEAST FUNCTIONAL SCREENS PREDICT A MODEL FOR PACKING THE TRANSMEMBRANE SEGMENTS OF THE OPEN KIR2.1 CHANNEL""
""THE KCSA CRYSTAL STRUCTURE AS A MODEL FOR THE CLOSED KIR3.2 CHANNEL""""CLOCKWISE ROTATION OF THE PORE-LINING TRANSMEMBRANE HELICES TO OPEN THE CHANNEL""; ""PROSPECTUS""; ""Calcium regulation of neuronal gene expression""; ""THE ROUTE OF CALCIUM ENTRY MATTERS: CHANNEL-ASSOCIATED SIGNALING COMPLEXES""; ""CALCIUM-REGULATED TRANSCRIPTION FACTORS: CREB""; ""CALCIUM REGULATION OF BDNF TRANSCRIPTION""; ""CONCLUSIONS/FUTURE DIRECTIONS""; ""Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans""; ""MATERIALS AND METHODS""; ""RESULTS""
""DISCUSSION""""Presenilin, Notch, and the genesis and treatment of Alzheimer�s disease""; ""MATERIALS AND METHODS""; ""PRESENILINS AS MEDIATORS OF INTRAMEMBRANOUS PROTEOLYSIS OF APP AND NOTCH""; ""DISCUSSION""; ""Delta FosB: A sustained molecular switch for addiction""; ""INDUCTION OF DELTA FOSB BY DRUGS OF ABUSE""; ""BIOCHEMICAL IDENTITY OF STABLE DELTA FOSB ISOFORMS""; ""ROLE OF DELTA FOSB IN BEHAVIORAL PLASTICITY TO DRUGS OF ABUSE""; ""TARGET GENES FOR DELTA FOSB""; ""ROLE OF DELTA FOSB IN MEDIATING “PERMANENT� PLASTICITY TO DRUGS OF ABUSE""
