附註:"Reprinted from the Proceedings of the National Academy of Sciences of the United States of America, volume 97, p. 11690-11857, October 24, 2000"--1st prelim page
Includes bibliographical references.
COLLOQUIUM ON Auditory Neuroscience: Development, Transduction, and Integration -- NATIONAL ACADEMY OF SCIENCES -- National Academy of Sciences Colloquia Bound Reprints Available -- Contents -- Introduction -- AUDITORY NEUROSCIENCE: DEVELOPMENT, TRANSDUCTION, AND INTEGRATION -- Development of the Inner Ear -- Transduction of Stimuli in the Inner Ear -- Processing of Sound in the Brainstem -- Analysis of Complex Sounds by the Forebrain -- Colloquium -- NOTCH SIGNALING IN THE DEVELOPMENT OF THE INNER EAR: LESSONS FROM DROSOPHILA -- Materials and Methods -- Results
DiscussionMOLECULAR GENETICS OF PATTERN FORMATION IN THE INNER EAR: DO COMPARTMENT BOUNDARIES PLAY A ROLE? -- Inner Ear Morphogenesis and Gene Expression Patterns -- Compartment and Boundary Model of Inner Ear Development -- Sensory Organs Arise at the Boundaries of Broader Gene Expression Domains -- The Endolymphatic Duct Arises at a Putative Medial-Lateral (M-L) Boundary -- Lineage-Restriction Compartments in the Dorsal Otocyst Revealed by Fate Mapping the Chicken Otic Cup -- Three Compartments Appear to Intersect at the Dorsal Pole of the Vesicle
Is the Hindbrain a Source of Patterning Information for Inner Ear A-P Compartments?Testing a Compartment Boundary Model of Ear Morphogenesis -- PATTERNING OF THE MAMMALIAN COCHLEA -- Gross Development of the Cochlea -- Gross Patterning of the Cochlea -- Conclusion -- CELLULAR STUDIES OF AUDITORY HAIR CELL REGENERATION IN BIRDS -- Hair Cells: Old and New -- Methods for Stimulating Hair Cell Regeneration in the Basilar Papilla -- Avian Hair Cell Progenitors: Identity and Behavior -- Repatterning the Mature Sensory Epithelium -- What�s Wrong with Us?
HAIR CELL RECOVERY IN MITOTICALLY BLOCKED CULTURES OF THE BULLFROG SACCULEMitotic HC Regeneration -- Nonmitotic HC Regeneration -- Normal and Mitotically Blocked Cultures of the Bullfrog Saccule -- Cell Proliferation in Saccular Cultures -- Morphology and Immunoreactivity in MBC Cultures -- Morphology and Immunoreactivity in MBGT Cultures -- HC Loss and Recovery in MBGT Cultures -- Transitional Cells and Immature Hair Cells in MBGT Cultures -- Scar Formation and SC Loss During HC Recovery -- Conclusions
TWO MECHANISMS FOR TRANSDUCER ADAPTATION IN VERTEBRATE HAIR CELLSTransduction Model -- Calcium Metabolism -- Adaptation -- Future Directions -- COCHLEAR MECHANISMS FROM A PHYLOGENETIC VIEWPOINT -- The Tympanic Middle Ear as the Initiator of Profound Change -- The Lineages of Modern Amniotes and Their Characteristic Hearing-Organ Morphologies -- Frequency-Selectivity Mechanisms and Tonotopicity from a Phylogenetic Viewpoint -- Coding of Intensity from a Phylogenetic Viewpoint -- The Phytogeny of the Cochlear Amplifier
