附註:"Published in cooperation with NATO Scientific Affairs Division."
"Proceedings of the NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions, 10-13 April 2002, Pisa, Italy"--Title page verso
Includes bibliographical references and index.
Oxidative signaling and glutathione synthesis -- Cell survival and changes in gene expression in cells unable to synthesize glutathione -- Role of glutathione in the regulation of liver metabolism -- Glutathione transport in the endo/sarcoplasmic reticulum -- Role of ascorbate in oxidative protein folding -- Cytophotometric investigations on oscillating thiol-disulfide equilibria and oxidized protein sulfur -- Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals -- the role of glutathione -- Thiols as major determinants of the total antioxidant capacity -- Enzymes of the thio9l-dependent hydroperoxide metabolism in pathogens as potential drug targets -- Is there a role of glutathione peroxidases in signaling and differentiation? -- Multidrug resistance-associated proteins: export pumps for conjugates with glutathione, glucuronate or sulfate -- Detoxification of eletrophilic compounds by glutathione s-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs? -- Transcriptional regulation of glutathione s-transferase P1-1 in human leukemia -- Mechanism of [gamma]-glutamyltranspeptidase folding and activation in the endoplasmic reticulum.
The role of [gamma]-glutamyl transpeptidase in the biosynthesis of glutathione -- Role of [gamma]-glutamyltransferase in the homeostasis of glutathione during oxidative and nitrosative stress -- The importance of gamma-glutamyl transferase in lung glutathione homeostasis and antioxidant defense -- The role of gamma-glutamyltranspeptidase in the metabolism and cytotoxicity of 4-hydroxynonenal-glutathione conjugate: evidence and hypothesis -- [gamma]-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes -- Serum gamma-glutamyl transpeptidase: a prognostic marker in cardiovascular diseases -- Lipoic acid: a multifunctional antioxidant -- Is glutathione an important neuroprotective effector molecule against amyloid beta toxicity? -- Antioxidants in cancer therapy: is there a rationale to recommend antioxidants during cancer therapy? -- Disulfide exchange in CD4 -- Redox regulation in protein folding and chaperone function -- Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus -- Analytical developments in the assay of intra- and extracellular GSH homeostasis -- Signalling potential and protein modifying ability of physiological thiols -- Redox signaling and the map kinase pathways -- Redox regulation of mitochondrial permeability transition: contrasting effects of lipoic acid and its positively charged analog LA-plus -- Redox state of glutathione and.
摘要:This volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place.
