附註:Includes bibliographical references and index.
Machine derived contents note: Preface xvii -- 1. EMT Concept and Examples from the Vertebrate Embryo 1 -- Elizabeth D. Hay -- Formation of the Mesenchymal Cell in the Embryo 2 -- Definition of the Mesenchymal Cell 4 -- Examples of EMT in Higher Vertebrate Embryos 4 -- 2. Epithelium-Mesenchyme Transitions Are Crucial Morphogenetic -- Events Occurring During Early Development 12 -- Olivier Morali, Pierre Savagner and Lionel Larue -- Supracellular Architecture: The Dichotomy Between Epithelium -- and Mesenchyme 14 -- Embryonic Morphogenesis: A Harmonious Series of Transitions -- from One Cellular Architectural Type to Another 15 -- 3. The Neural Crest: A Model Developmental EMT 29 -- Donald F. Newgreen and Sonja J. McKeown -- The NC Is a Valuable Model for EMT 29 -- Defining the NC 29 -- The EMT of the NC Is Stereotyped 29 -- The Induction, EMT and Migration of NC Are Linked 32 -- The NC Is Induced by Cell Interactions 32 -- Genes and Molecules in the NC during Induction, EMT -- and Migration 33 -- Specific Transcription Factors Are Expressed by Nascent NC Cells 33 -- Motor Molecules and Genes in the NC That Contribute to EMT 34 -- 4. Epithelial-Mesenchymal Transformation in the Embryonic Heart 40 -- Raymond B. Runyan, Ronald L. Heimark, Todd D. Camenisch -- and Scott E. Klewer -- Description of EMT in Vivo 41 -- Development of Collagen Gel Culture 43 -- Identification of Components of the EMT Process 43 -- TGFb As a Mediator of EMT 45 -- TGFb Receptors 46 -- TGFb Activation 46 -- Extracellular Matrix in EMT 47 -- Other Growth Factors in EMT 48 -- Signal Transduction during EMT 48 -- Cell-Cell Regulation of EMT 49 -- Transcriptional Regulation of EMT 49 -- Clinical Significance of EMT in the Heart 50 -- Questions and Future Directions 50 -- 5. Epithelial-Extracellular Matrix (Cell-ECM) Interactions in Hydra 56 -- Michael P. Sarras, Jr. -- General Introduction to Hydra Structure and Tissue Dynamics 56 -- Composition and Supramolecular Organization of Hydra -- Extrac
Newgreen, Hiroshi Sato -- and Erik W. Thompson -- General Considerations of the EMT 297 -- Matrix Metalloproteases 298 -- MMPs in Carcinoma Model Systems for the EMT 300 -- MMPs in Developmental EMT Systems 306 -- Regulation of MMPs by EMT-Associated Transcription Factors 309 -- Index 317.
摘要:Epithelial phenotype is a dynamic stage of differentiation. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). This book introduces the concept of EMT. Part one describes main examples and models and part two reviews specific EMT molecular pathways.
