Medical cannabis and the effects of cannabinoids on fighting cancer, multiple sclerosis, epilepsy, Parkinson's, and other neurodegenerative diseases[electronic resource]
- 其他作者: Zeine, Rana, , Teasdale, Brian. , IGI Global.
- 出版: Hershey, Pennsylvania : IGI Global 2023.
- 稽核項: 1 online resource (406 p.).
- 標題: Therapeutic use. , Neurodegenerative Diseases drug therapy. , therapeutic use. , Medical Marijuana , Cannabinoids analysis. , Medical Marijuana therapeutic use. , Marijuana , drug therapy. , Cannabinoids , analysis. , Marijuana Therapeutic use. , Electronic books. , Neurodegenerative Diseases
- ISBN: 1668456524 , 9781668456521
- 試查全文@TNUA:
- 附註: Includes bibliographical references and index. Chapter 1. Medicinal cannabis for Alzheimer's disease -- Chapter 2. Protective effects of cannabis in neuroinflammation-mediated Alzheimer's disease -- Chapter 3. Cannabinoid efficacy for developmental epileptic encephalopathy (DEE)intractable seizure control: a systematic review of the literature -- Chapter 4. Medical cannabis in the treatment of epilepsy -- Chapter 5. Anti-tumor effects of cannabinoids in brain, lung, breast, prostate, colorectal, and pancreatic cancers: a systematic review of the literature -- Chapter 6. Cannabinoid neurobiology and medical cannabis intervention for amyotrophic lateral sclerosis (ALS): understanding the molecular mechanisms of action -- Chapter 7. Role of cannabinoids in the regulation of amyotrophic lateral sclerosis (ALS) -- Chapter 8. Neurobiology of cannabinoids and medical cannabis in therapeutic intervention for multiple sclerosis: understanding the molecular mechanisms of action -- Chapter 9. Pros and cons of cannabinoids as a potential therapeutic target for treating Parkinson's disease: cannabinoid receptor-mediated mechanism of action -- Chapter 10. The uses of cannabinoids in medicine and their spectroscopic applications -- Chapter 11. Therapeutic advantages of cannabimimetic plants: can they substitute medical cannabis? -- Chapter 12. History and legislative changes governing medical cannabis in Indonesia -- Chapter 13. A case study on the integration of cannabis law enforcement in new jersey.
- 摘要: "Research into the efficacy of medical marijuana is currently at different stages for different types of diseases. The most advanced studies in humans provide moderate-quality evidence for moderate effects that benefit patients withParkinson Disease and Multiple Sclerosis. There is also low-quality evidence for mild-to-moderate effects that benefit patients with Epilepsy and Huntington Disease. The best success in reducing spasticity, relieving pain, decreasing bladder overactivity, reducing anxiety and improving quality of sleep was achieved using a 50:50 mixture of Cannabidiol (CBD):delta-9-THC. Reducing frequency and duration of seizures in children with intractable epilepsy is achieved using CBD alone. Future studies can hopefully improve the quality of evidence by including control groups, recruiting more participants, and following them up for longer periods of time. In the meanwhile, the cellular and molecular mechanisms responsible for alleviating these neurological symptoms in animals and humans are being investigated. Some of the anti-inflammatory and neuroprotective effects are mediated through one or both of the cannabinoid receptors CB1 and CB2 distributed on immune and neural cells, while some of the anti-epileptic effects are mediated through other receptors found in the central nervous system. Animal studies show that cannabinoids are effective anti-inflammatory and anti-tumor agents. In experimental xenograft models for brain cancer, lung, breast, colorectal, pancreatic and other cancers, treatment with either CBD alone or in mixtures with THC, significantly shrinks the tumors, inhibits tumor cell migration, slows metastasis, disrupts tumor blood vessel formation (angiogenesis), inhibits tumor cell proliferation and increases tumor cell death. Future studies are warranted to investigate these anti-tumor effects in human cancer patients, however, a small study onadozen brain cancer patients demonstrated a modest increase in overall survival, and a
- 電子資源: https://dbs.tnua.edu.tw/login?url=http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/978-1-6684-5652-1
- 系統號: 005331109
- 資料類型: 電子書
- 讀者標籤: 需登入
- 引用網址: 複製連結
Research on the therapeutic efficacy of cannabinoids has demonstrated that cannabidiol (CBD), either alone or in 1:1 mixtures with delta-9-tetrahydrocannabinol (THC), can effectively treat animals in experimental models of neuroinflammatory, demyelinative, neurodegenerative, neuropsychiatric, and neoplastic diseases. Short-term, small-scale, human cohorts, observational studies, randomized, non-randomized, placebo-controlled, and uncontrolled clinical trials have provided low-certainty and moderate-certainty evidence that medical marijuana can reduce spasticity, neuropathic pain, neuroinflammation, anxiety, sleep disturbance, urinary bladder dysfunction, frequency and duration of seizure, tumor size, and metastasis as well as promote overall cancer survival. Medical Marijuana and the Effects of Cannabinoids on Fighting Cancer, Multiple Sclerosis, Epilepsy, Parkinson's, and Other Neurodegenerative Diseases presents the findings from clinical and basic medical scientists who are investigating the cellular and molecular mechanisms of cannabinoid-mediated inhibition of innate and adaptive immune responses, mobilization of myeloid-derived immunosuppressive cells, enhancement of neuroprotection, facilitation of oligodendrocyte survival, promotion of CNS progenitor cell differentiation to support regeneration and remyelination, arrest of tumor cell proliferation, decrease in tumor cell adhesion, disruption of tumor angiogenesis, inhibition of endothelial cells, and prevention of cancer metastasis by inhibition of cell migration. The chapters further discuss pharmacologic challenges and precisely how the delicate balance between the opposing effects of various types of cannabinoid receptors can be controlled by manipulating specific membrane channels and signaling pathways to achieve favorable long-term clinicopathologic outcomes in oncology and neurology. Covering topics such as neurodegenerative diseases, spectroscopic applications, and ethical issues, this premier reference source is an essential resource for medical professionals, pharmacists, hospital administrators, government officials, students and faculty of higher education, librarians, researchers, and academicians.
來源: Google Book
來源: Google Book
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