附註:Includes bibliographical references and index.
Front Cover -- Microbiome, Immunity, Digestive Health and Nutrition -- Copyright Page -- Dedication -- Contents -- List of contributors -- Preface -- I. Microbiome and Human Health: An Introduction -- 1 Oral microbiome: a gateway toyour health -- 1.1 Introduction -- 1.2 Oral microbiome and oral disease -- 1.2.1 Caries -- 1.2.2 Periodontal disease -- 1.2.3 Oral cancer -- 1.3 Oral microbiome and systemic disease -- 1.3.1 Alzheimer's disease -- 1.3.2 Cardiovascular disease -- 1.3.3 Diabetes -- 1.4 Concluding remarks -- Acknowledgments -- References
2 Influence of microbiome in shaping the newborn immune system: an overview -- 2.1 Introduction -- 2.2 How the microbiota shapes the development of immunity in early life -- 2.3 Influence of the microbiota on the development and function of specific immune cell subsets in early life -- 2.3.1 Myeloid cells -- 2.3.1.1 Erythrocytes in the spleen -- 2.3.1.2 Myeloid-derived suppressor cells -- 2.3.2 Lymphoid cells -- 2.3.2.1 T cell repertoire -- 2.3.2.2 CD4+ T cells -- 2.3.2.3 Th1 and Th2 Cells -- 2.3.2.4 Th17 cells -- 2.3.2.5 T regulatory cells -- 2.3.2.6 CD8+ T cells
2.3.2.7 Innate-like lymphocytes -- 2.3.2.7.1 Invariant natural killer T cells -- 2.3.2.8 Innate lymphoid cells -- 2.3.2.8.1 NK cells -- 2.3.2.9 B cells -- 2.3.3 Epithelial cells -- 2.4 Conclusion -- Author disclosure statement -- References -- 3 Impact of the gut microbiome on human health and diseases -- 3.1 Introduction -- 3.1.1 Definition of microbiome -- 3.1.2 Uneven distribution of microbiota across various sites and organs of the body: reasons and implications -- 3.2 The gut as the most significant niche of the human microbiome
3.2.1 Establishment of the gut microbiome: journey from womb to adulthood -- 3.2.2 Heritable component of the gut microbiome -- 3.2.3 Role of diet and other environmental factors in shaping the gut microbiome -- 3.3 Physiological roles of the gut microbiome -- 3.3.1 Gut Microbiota in metabolism -- 3.3.2 Gut microbiota in boosting immune response: role of short-chain fatty acids and cross-talk with diet -- 3.3.3 The role of the gut microbiome in the development of gut-associated lymphoid tissue -- 3.3.4 Gut microbes as a defense mechanism against pathogens
3.3.5 Role in cognitive development: the gut-brain axis -- 3.3.6 The gut microbiome as a human organ -- 3.4 Dysbiosis of normal flora: implications in human diseases and intervention strategies -- 3.4.1 Gut microbiome in human ailments -- 3.4.1.1 Obesity -- 3.4.1.2 Diabetes -- 3.4.1.3 Hypertension -- 3.4.1.4 Cancer -- 3.4.1.5 Inflammatory bowel disease -- 3.4.1.6 Gout -- 3.4.1.7 Depression -- 3.4.1.8 Rheumatoid arthritis -- 3.4.1.9 Infant health -- 3.4.2 How to keep the gut happy: prebiotics, probiotics, postbiotics, and synbiotics -- 3.5 Concluding remarks -- Acknowledgments -- References
